ISHNE AF World-Wide Internet Symposium II / 2007
  Major trials and guidelines
New Major Trials and Guidelines by date
ARMYDA-3
Patti G, Chello M, Candura D, Pasceri V, D'Ambrosio A, Covino E, Di Sciascio G
Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery: results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study.
Circulation. 2006 Oct 3;114(14):1455-61. Epub 2006 Sep 25.


Angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist
Yamashita T, Ogawa S, Aizawa Y, Atarashi H, Inoue H, Ohe T, Okumura K, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E; J-RHYTHM II Investigators.
Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension.
Circ J. 2006 Oct;70(10):1318-21.


RACE
Hagens VE, Rienstra M, Van Veldhuisen DJ, Crijns HJ, Van Gelder IC.t
Determinants of sudden cardiac death in patients with persistent atrial fibrillation in the rate control versus electrical cardioversion (RACE) study.
Am J Cardiol. 2006 Oct 1;98(7):929-32. Epub 2006 Aug 11.


Verapamil versus digoxin and acute versus routine serial cardioversion
Hemels ME, Van Noord T, Crijns HJ, Van Veldhuisen DJ, Veeger NJ, Bosker HA, Wiesfeld AC, Van den Berg MP, Ranchor AV, Van Gelder IC.
Verapamil versus digoxin and acute versus routine serial cardioversion for the improvement of rhythm control for persistent atrial fibrillation.
J Am Coll Cardiol. 2006 Sep 5;48(5):1001-9. Epub 2006 Aug 17.


VRR study
Ciaramitaro G, Sgarito G, Solimene F, Maglia G, Vicentini A, DI Donato G, Raciti G, Parrinello G, Del Giudice GB. Role of rate control and regularization through pacing in patients with chronic atrial fibrillation and preserved ventricular function: the VRR study.
Pacing Clin Electrophysiol. 2006 Aug;29(8):866-74.


Veterans Affairs Cooperative Studies Program Substudy
Singh SN, Tang XC, Singh BN, Dorian P, Reda DJ, Harris CL, Fletcher RD, Sharma SC, Atwood JE, Jacobson AK, Lewis HD Jr, Lopez B, Raisch DW, Ezekowitz MD; SAFE-T Investigators.
Quality of life and exercise performance in patients in sinus rhythm versus persistent atrial fibrillation: a Veterans Affairs Cooperative Studies Program Substudy.
J Am Coll Cardiol. 2006 Aug 15;48(4):721-30. Epub 2006 Jul 24.


Inhibition of renin-angiotensin system
Anand K, Mooss AN, Hee TT, Mohiuddin SM.
Meta-analysis: inhibition of renin-angiotensin system prevents new-onset atrial fibrillation.
Am Heart J. 2006 Aug;152(2):217-22.


QOLAF Study
Tsuneda T, Yamashita T, Fukunami M, Kumagai K, Niwano S, Okumura K, Inoue H.
Rate control and quality of life in patients with permanent atrial fibrillation: the Quality of Life and Atrial Fibrillation (QOLAF) Study.
Circ J. 2006 Aug;70(8):965-70.


OPTIC
Hohnloser SH, Dorian P, Roberts R, Gent M, Israel CW, Fain E, Champagne J, Connolly SJ.
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial.
Circulation. 2006 Jul 11;114(2):104-9. Epub 2006 Jul 3.


Stroke prevention
Cooper NJ, Sutton AJ, Lu G, Khunti K.
Mixed comparison of stroke prevention treatments in individuals with nonrheumatic atrial fibrillation.
Arch Intern Med. 2006 Jun 26;166(12):1269-75.


Atrial-based pacing compared with ventricular pacing
Healey JS, Toff WD, Lamas GA, Andersen HR, Thorpe KE, Ellenbogen KA, Lee KL, Skene AM, Schron EB, Skehan JD, Goldman L, Roberts RS, Camm AJ, Yusuf S, Connolly SJ.
Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data.
Circulation. 2006 Jul 4;114(1):11-7. Epub 2006 Jun 26.


Cardiac resynchronization
Hoppe UC, Casares JM, Eiskjaer H, Hagemann A, Cleland JG, Freemantle N, Erdmann E.
Effect of cardiac resynchronization on the incidence of atrial fibrillation in patients with severe heart failure.
Circulation. 2006 Jul 4;114(1):18-25. Epub 2006 Jun 26.


PITAGORA
Gulizia M, Mangiameli S, Orazi S, Chiaranda G, Boriani G, Piccione G, DiGiovanni N, Colletti A, Puntrello C, Butera G, Vasco C, Vaccaro I, Scardace G, Grammatico A; PITAGORA (Prevention Investigation and Treatment: A Group for Observation and Research on Atrial arrhythmias) Investigators. 
Randomized comparison between Ramp and Burst+ atrial antitachycardia pacing therapies in patients suffering from sinus node disease and atrial fibrillation and implanted with a DDDRP device.
Europace. 2006 Jul;8(7):465-73.


COMPACT
Kamei M, Morita S, Hayashi Y, Kanmura Y, Kuro M.
Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT).
Cardiovasc Drugs Ther. 2006 Jun;20(3):219-27.


Off-pump coronary artery bypass (OPCAB) versus CPB techniques in the elderly
Panesar SS, Athanasiou T, Nair S, Rao C, Jones C, Nicolaou M, Darzi A.
Early outcomes in the elderly: a meta-analysis of 4921 patients undergoing coronary artery bypass grafting--comparison between off-pump and on-pump techniques.
Heart. 2006 Dec;92(12):1808-16. Epub 2006 Jun 14.


SPORTIF
Gomberg-Maitland M, Wenger NK, Feyzi J, Lengyel M, Volgman AS, Petersen P, Frison L, Halperin JL.
Anticoagulation in women with non-valvular atrial fibrillation in the stroke prevention using an oral thrombin inhibitor (SPORTIF) trials.
Eur Heart J. 2006 Aug;27(16):1947-53. Epub 2006 Jun 14.


ACTIVE W
ACTIVE Writing Group on behalf of the ACTIVE Investigators; Connolly S, Pogue J, Hart R, Pfeffer M, Hohnloser S, Chrolavicius S, Pfeffer M, Hohnloser S, Yusuf S.
Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial.
Lancet. 2006 Jun 10;367(9526):1903-12.


Pilsicainide Suppression Trial
Okishige K, Fukunami M, Kumagai K, Atarashi H, Inoue H; Pilsicainide Suppression Trial for Persistent Atrial Fibrillation II Investigators.
Pharmacological conversion of persistent atrial fibrillation into sinus rhythm with oral pilsicainide: pilsicainide suppression trial for persistent atrial fibrillation II.
Circ J. 2006 Jun;70(6):657-61. Erratum in: Circ J. 2006 Jul;70(7):945.


CHARM program
Olsson LG, Swedberg K, Ducharme A, Granger CB, Michelson EL, McMurray JJ, Puu M, Yusuf S, Pfeffer MA; CHARM Investigators.
Atrial fibrillation and risk of clinical events in chronic heart failure with and without left ventricular systolic dysfunction: results from the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) program.
J Am Coll Cardiol. 2006 May 16;47(10):1997-2004. Epub 2006 Apr 27.


HOBIPACE
Kindermann M, Hennen B, Jung J, Geisel J, Bohm M, Frohlig G.
Biventricular versus conventional right ventricular stimulation for patients with standard pacing indication and left ventricular dysfunction: the Homburg Biventricular Pacing Evaluation (HOBIPACE).
J Am Coll Cardiol. 2006 May 16;47(10):1927-37. Epub 2006 Apr 24.


Atrial fibrillation ablation
Fisher JD, Spinelli MA, Mookherjee D, Krumerman AK, Palma EC.
Atrial fibrillation ablation: reaching the mainstream.
Pacing Clin Electrophysiol. 2006 May;29(5):523-37. Review.


Surgical ablation
Barnett SD, Ad N.
Surgical ablation as treatment for the elimination of atrial fibrillation: a meta-analysis.
J Thorac Cardiovasc Surg. 2006 May;131(5):1029-35.


Bleeding in patients on ximelagatran or warfarin
Douketis JD, Arneklev K, Goldhaber SZ, Spandorfer J, Halperin F, Horrow J.
Comparison of bleeding in patients with nonvalvular atrial fibrillation treated with ximelagatran or warfarin: assessment of incidence, case-fatality rate, time course and sites of bleeding, and risk factors for bleeding.
Arch Intern Med. 2006 Apr 24;166(8):853-9.


Antiarrhythmic drugs
Lafuente-Lafuente C, Mouly S, Longas-Tejero MA, Mahe I, Bergmann JF.
Antiarrhythmic drugs for maintaining sinus rhythm after cardioversion of atrial fibrillation: a systematic review of randomized controlled trials.
Arch Intern Med. 2006 Apr 10;166(7):719-28. Review.


MERIT-HF Study
van Veldhuisen DJ, Aass H, El Allaf D, Dunselman PH, Gullestad L, Halinen M, Kjekshus J, Ohlsson L, Wedel H, Wikstrand J; on behalf of the MERIT-HF Study Group.
Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study.
Eur J Heart Fail. 2006 Aug;8(5):539-46. Epub 2006 Mar 29.


Circumferential pulmonary-vein ablation
Oral H, Pappone C, Chugh A, Good E, Bogun F, Pelosi F Jr, Bates ER, Lehmann MH, Vicedomini G, Augello G, Agricola E, Sala S, Santinelli V, Morady F.
Circumferential pulmonary-vein ablation for chronic atrial fibrillation.
N Engl J Med. 2006 Mar 2;354(9):934-41.


Japan Atrial Fibrillation Stroke Trial
Sato H, Ishikawa K, Kitabatake A, Ogawa S, Maruyama Y, Yokota Y, Fukuyama T, Doi Y, Mochizuki S, Izumi T, Takekoshi N, Yoshida K, Hiramori K, Origasa H, Uchiyama S, Matsumoto M, Yamaguchi T, Hori M; Japan Atrial Fibrillation Stroke Trial Group.
Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke Trial.
Stroke. 2006 Feb;37(2):447-51. Epub 2005 Dec 29.


NASPEAF
Perez-Gomez F, Salvador A, Zumalde J, Iriarte JA, Berjon J, Alegria E, Almeria C, Bover R, Herrera D, Fernandez C.
Effect of antithrombotic therapy in patients with mitral stenosis and atrial fibrillation: a sub-analysis of NASPEAF randomized trial.
Eur Heart J. 2006 Apr;27(8):960-7. Epub 2005 Dec 5.


PAVE study
Doshi RN, Daoud EG, Fellows C, Turk K, Duran A, Hamdan MH, Pires LA; PAVE Study Group.
Left ventricular-based cardiac stimulation post AV nodal ablation evaluation (the PAVE study).
J Cardiovasc Electrophysiol. 2005 Nov;16(11):1160-5.


Left mitral isthmus ablation
Fassini G, Riva S, Chiodelli R, Trevisi N, Berti M, Carbucicchio C, Maccabelli G, Giraldi F, Bella PD.
Left mitral isthmus ablation associated with PV Isolation: long-term results of a prospective randomized study.
J Cardiovasc Electrophysiol. 2005 Nov;16(11):1150-6.


Catheter Ablation For The Cure Of Atrial Fibrillation Study
Stabile G, Bertaglia E, Senatore G, De Simone A, Zoppo F, Donnici G, Turco P, Pascotto P, Fazzari M, Vitale DF.
Catheter ablation treatment in patients with drug-refractory atrial fibrillation: a prospective, multi-centre, randomized, controlled study (Catheter Ablation For The Cure Of Atrial Fibrillation Study).
Eur Heart J. 2006 Jan;27(2):216-21. Epub 2005 Oct 7.


Amiodarone prophylaxis
Aasbo JD, Lawrence AT, Krishnan K, Kim MH, Trohman RG.
Amiodarone prophylaxis reduces major cardiovascular morbidity and length of stay after cardiac surgery: a meta-analysis.
Ann Intern Med. 2005 Sep 6;143(5):327-36. Summary for patients in: Ann Intern Med. 2005 Sep 6;143(5):I26.


Perindopril-based blood pressure-lowering. PROGRESS
Arima H, Hart RG, Colman S, Chalmers J, Anderson C, Rodgers A, Woodward M, MacMahon S, Neal B; PROGRESS Collaborative Group.
Perindopril-based blood pressure-lowering reduces major vascular events in patients with atrial fibrillation and prior stroke or transient ischemic attack.
Stroke. 2005 Oct;36(10):2164-9. Epub 2005 Sep 1.


DAAFI
McAlister FA, Man-Son-Hing M, Straus SE, Ghali WA, Anderson D, Majumdar SR, Gibson P, Cox JL, Fradette M; Decision Aid in Atrial Fibrillation (DAAFI) Investigators.
Impact of a patient decision aid on care among patients with nonvalvular atrial fibrillation: a cluster randomized trial.
CMAJ. 2005 Aug 30;173(5):496-501.


LAAOS
Healey JS, Crystal E, Lamy A, Teoh K, Semelhago L, Hohnloser SH, Cybulsky I, Abouzahr L, Sawchuck C, Carroll S, Morillo C, Kleine P, Chu V, Lonn E, Connolly SJ.
Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke.
Am Heart J. 2005 Aug;150(2):288-93.


Electrical cardioversion
Mead GE, Elder AT, Flapan AD, Kelman A.
Electrical cardioversion for atrial fibrillation and flutter.
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD002903. Review.


Oral anticoagulants for preventing stroke
Aguilar MI, Hart R.
Oral anticoagulants for preventing stroke in patients with non-valvular atrial fibrillation and no previous history of stroke or transient ischemic attacks.
Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001927. Review.


AFFIRM: Asymptomatic atrial fibrillation
Flaker GC, Belew K, Beckman K, Vidaillet H, Kron J, Safford R, Mickel M, Barrell P; AFFIRM Investigators.
Asymptomatic atrial fibrillation: demographic features and prognostic information from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Am Heart J. 2005 Apr;149(4):657-63.


AFFIRM: Factors affecting bleeding risk during anticoagulant therapy
DiMarco JP, Flaker G, Waldo AL, Corley SD, Greene HL, Safford RE, Rosenfeld LE, Mitrani G, Nemeth M; AFFIRM Investigators.
Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Am Heart J. 2005 Apr;149(4):650-6.


AFFIRM: Clinical factors
Curtis AB, Gersh BJ, Corley SD, DiMarco JP, Domanski MJ, Geller N, Greene HL, Kellen JC, Mickel M, Nelson JD, Rosenberg Y, Schron E, Shemanski L, Waldo AL, Wyse DG; AFFIRM Investigators.
Clinical factors that influence response to treatment strategies in atrial fibrillation: the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Am Heart J. 2005 Apr;149(4):645-9.


Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers
Healey JS, Baranchuk A, Crystal E, Morillo CA, Garfinkle M, Yusuf S, Connolly SJ.
Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysis.
J Am Coll Cardiol. 2005 Jun 7;45(11):1832-9.


AFFIRM: Stroke events
Sherman DG, Kim SG, Boop BS, Corley SD, Dimarco JP, Hart RG, Haywood LJ, Hoyte K, Kaufman ES, Kim MH, Nasco E, Waldo AL; National Heart, Lung, and Blood Institute AFFIRM Investigators.
Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study.
Arch Intern Med. 2005 May 23;165(10):1185-91.


SAFE-T
Singh BN, Singh SN, Reda DJ, Tang XC, Lopez B, Harris CL, Fletcher RD, Sharma SC, Atwood JE, Jacobson AK, Lewis HD Jr, Raisch DW, Ezekowitz MD; Sotalol Amiodarone Atrial Fibrillation Efficacy Trial (SAFE-T) Investigators.
Amiodarone versus sotalol for atrial fibrillation.
N Engl J Med. 2005 May 5;352(18):1861-72.


MAGNESIUM
Miller S, Crystal E, Garfinkle M, Lau C, Lashevsky I, Connolly SJ.
Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis.
Heart. 2005 May;91(5):618-23. Review.


COMET
Swedberg K, Olsson LG, Charlesworth A, Cleland J, Hanrath P, Komajda M, Metra M, Torp-Pedersen C, Poole-Wilson P.
Prognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with beta-blockers: results from COMET.
Eur Heart J. 2005 Jul;26(13):1303-8. Epub 2005 Mar 14.


SMAAF
Voller H, Glatz J, Taborski U, Bernardo A, Dovifat C, Heidinger K.
Self-management of oral anticoagulation in nonvalvular atrial fibrillation (SMAAF study).
Z Kardiol. 2005 Mar;94(3):182-6.


LIFE
Wachtell K, Lehto M, Gerdts E, Olsen MH, Hornestam B, Dahlof B, Ibsen H, Julius S, Kjeldsen SE, Lindholm LH, Nieminen MS, Devereux RB.
Angiotensin II receptor blockade reduces new-onset atrial fibrillation and subsequent stroke compared to atenolol: the Losartan Intervention For End Point Reduction in Hypertension (LIFE) study.
J Am Coll Cardiol. 2005 Mar 1;45(5):712-9.


SPORFIT V
Albers GW, Diener HC, Frison L, Grind M, Nevinson M, Partridge S, Halperin JL, Horrow J, Olsson SB, Petersen P, Vahanian A; SPORTIF Executive Steering Committee for the SPORTIF V Investigators.
Ximelagatran vs warfarin for stroke prevention in patients with nonvalvular atrial fibrillation: a randomized trial.
JAMA. 2005 Feb 9;293(6):690-8.


OPTIMAAL
Lehto M, Snapinn S, Dickstein K, Swedberg K, Nieminen MS; OPTIMAAL investigators.
Prognostic risk of atrial fibrillation in acute myocardial infarction complicated by left ventricular dysfunction: the OPTIMAAL experience.
Eur Heart J. 2005 Feb;26(4):350-6. Epub 2004 Dec 9.